prikaz prve stranice dokumenta Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification
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Scientific paper - Original scientific paper
Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification
Diagnostic Pathology, 6 (2011), 108; 1-8. https://doi.org/10.1186/1746-1596-6-108
Dekanic, Andrea; Dintinjana, Renata Dobrila; Budisavljevic, Ivana; Pecanic, Sanja; Zuvic Butorac, Marta; Jonjic, Nives

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Dekanic, A., Dintinjana, R. D., Budisavljevic, I., Pecanic, S., Zuvic Butorac, M. & Jonjic, N. (2011). Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification. Diagnostic Pathology, 6. (108), 1-8. doi: 10.1186/1746-1596-6-108

Dekanic, Andrea, et al. "Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification." Diagnostic Pathology, vol. 6, no. 108, 2011, pp. 1-8. https://doi.org/10.1186/1746-1596-6-108

Dekanic, Andrea, Renata Dobrila Dintinjana, Ivana Budisavljevic, Sanja Pecanic, Marta Zuvic Butorac and Nives Jonjic. "Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification." Diagnostic Pathology 6, no. 108 (2011): 1-8. https://doi.org/10.1186/1746-1596-6-108

Dekanic, A., et al. (2011) 'Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification', Diagnostic Pathology, 6(108), pp. 1-8. doi: 10.1186/1746-1596-6-108

Dekanic A, Dintinjana RD, Budisavljevic I, Pecanic S, Zuvic Butorac M, Jonjic N. Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification. Diagnostic Pathology [Internet]. 2011 November 03 [cited 2024 April 26];6(108):1-8. doi: 10.1186/1746-1596-6-108

A. Dekanic, R. D. Dintinjana, I. Budisavljevic, S. Pecanic, M. Zuvic Butorac and N. Jonjic, "Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification", Diagnostic Pathology, vol. 6, no. 108, pp. 1-8, November 2011. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:193:972799. [Accessed: 26 April 2024]

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Metadata
Title (english)Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification
AuthorAndrea Dekanic
AuthorRenata Dobrila Dintinjana
AuthorIvana Budisavljevic
AuthorSanja Pecanic
AuthorMarta Zuvic Butorac
AuthorNives Jonjic
Author's institutionUniversity of Rijeka
(Faculty of Biotechnology and Drug Development)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Oncology
Abstract (english)
Background: Prognostic and predictive significance of epidermal growth factor receptor (EGFR) in colorectal carcinomas (CRCs) is still controversial. The aim of the present study was to explore and correlate membrane and nuclear EGFR and cyclin-D1 protein expression with EGFR gene status of tumor cells. Methods: Immunohistochemical and FISH analysis was performed on 135 archival formalin fixed and paraffin embedded CRCs. Results: Strong membrane and strong nuclear EGFR staining was detected in 16% and 57% of cases, respectively, and strong cyclin-D1 expression in 57% samples. Gene EGFR amplification was identified in 5.9% and polysomy in 7.4% of cases, while 87% showed no EGFR gene changes. A statistically significant difference was only found between tumor grade and expression of membrane EGFR, while nuclear EGFR and cyclin-D1 expression was not associated with the clinicopathologic characteristics analyzed. Tumor cells displaying gene amplification and strong protein membrane EGFR expression overlapped, while EGFR gene status showed no correlation with nuclear EGFR and cyclin-D1. There was no association between membrane EGFR and cyclin-D1, whereas nuclear EGFR expression was strongly related to cyclin-D1 expression. Conclusions: Study results revealed heterogeneity among CRCs, which could have a predictive value by identifying biologically and probably clinically different subsets of tumors with the possibly diverse response to anti-EGFR therapies.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleDiagnostic Pathology
Numberingvol. 6, no. 108, pp. 1-8
e-ISSN1746-1596
DOIhttps://doi.org/10.1186/1746-1596-6-108
URN:NBNurn:nbn:hr:193:972799
Publication2011-11-03
Document URLhttps://diagnosticpathology.biomedcentral.com/articles/10.1186/1746-1596-6-108
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
RepositoryRepository of the University of Rijeka, Faculty of Biotechnology and Drug Development
Created on2018-09-30 16:07:09