This research monograph consists of 29 articles that address the causes and consequences of the growing uncertainties in the post-COVID world. The chapters of the monograph deal with various areas related to the main topic of the monograph. Part of the research deals with the effects of the uncertain social and economic environment on companies. These contributions address the dynamics of the labor market, the legal and economic aspects of attracting investment, the interactions between entrepreneurship and digitalization and the impact of uncertainty on different sectors of the economy. The second group of contributions deals with the macroeconomic impact of less predictable economic indicators. Contributions address government processes responding to the potential crisis arising from changes in the tax system, methodological challenges important for accurate macroeconomic and government reporting, changes and responses within the government financial system, legal aspects the supranational and national economic systems as well as with the various issues of finance and management of local authorities in times of uncertainty. A large part of the paper deals with the exponential impact of ICT and digitalization processes on various economic sectors. The new challenges of marketing, which is increasingly shifting into the digital space, are also discussed. Finally, a number of contributions address the emerging problems of migration, which is fundamentally affecting the labor market across Europe and worldwide, looking in particular at the state of student mobility and the position of universities in this dynamic environment of human capital mobility. As our authors explain, the transition to a sustainable economy has become one of the EU’s key policy priorities in recent years, as it is “essential for the well-being of our society and our planet”. The “green” and “digital” or “dual” transition to a sustainable economy is an ongoing process that must be facilitated not only by a strong political commitment, but also by a solid legal framework. This trend of transition confronts current trends of deregulation and globalization of markets, which increase the impact of risks on business operations, while the identification and management of various forms of risks by achieving the fundamental objective increasingly contributes to keeping a business functioning in the modern can survive and work successfully in an economic environment. On the other hand, at the global political level, we are observing strong trends of deglobalization, affecting certain sectors such as energy, technology and other goods that are defined as sensitive to national security and interests. All these contributions give this monograph the traditional perspective dictated by the objectives of the conference, which includes both a transdisciplinary and an interdisciplinary perspective on the challenges of the growing uncertainties of the post-COVID world. We are sure that the scientific contributions will provide interested readers with important information and arguments. We therefore hope you enjoy reading our authors’ contributions and hope that you will regularly attend our annual conference.