NCR1-deficiency diminishes the generation of protective murine cytomegalovirus antibodies by limiting follicular helper T-cell maturation

Miletić, Antonija; Lenartić, Maja; Popović, Branka; Brizić, Ilija; Tršan, Tihana; Miklić, Karmela; Mandelboim, Ofer; Krmpotić, Astrid; Jonjić, Stipan

doi:10.1002/eji.201646763

prikaz prve stranice dokumenta NCR1-deficiency diminishes the generation of protective murine cytomegalovirus antibodies by limiting follicular helper T-cell maturation

Scientific paper - Original scientific paper

NCR1-deficiency diminishes the generation of protective murine cytomegalovirus antibodies by limiting follicular helper T-cell maturation

European Journal of Immunology, 47 (2017), 9; 1443-1456. https://doi.org/10.1002/eji.201646763

Miletić, Antonija; Lenartić, Maja; Popović, Branka; Brizić, Ilija; Tršan, Tihana; Miklić, Karmela; Mandelboim, Ofer; Krmpotić, Astrid; Jonjić, Stipan

Cite this document

APA 6th Edition

Miletić, A., Lenartić, M., Popović, B., Brizić, I., Tršan, T., Miklić, K. ... Jonjić, S. (2017). NCR1-deficiency diminishes the generation of protective murine cytomegalovirus antibodies by limiting follicular helper T-cell maturation. European Journal of Immunology, 47. (9), 1443-1456. doi: 10.1002/eji.201646763

MLA 8th Edition

Miletić, Antonija, et al. "NCR1-deficiency diminishes the generation of protective murine cytomegalovirus antibodies by limiting follicular helper T-cell maturation." European Journal of Immunology, vol. 47, no. 9, 2017, pp. 1443-1456. https://doi.org/10.1002/eji.201646763

Chicago 17th Edition

Miletić, Antonija, Maja Lenartić, Branka Popović, Ilija Brizić, Tihana Tršan, Karmela Miklić, Ofer Mandelboim, Astrid Krmpotić and Stipan Jonjić. "NCR1-deficiency diminishes the generation of protective murine cytomegalovirus antibodies by limiting follicular helper T-cell maturation." European Journal of Immunology 47, no. 9 (2017): 1443-1456. https://doi.org/10.1002/eji.201646763

Harvard

Miletić, A., et al. (2017) 'NCR1-deficiency diminishes the generation of protective murine cytomegalovirus antibodies by limiting follicular helper T-cell maturation', European Journal of Immunology, 47(9), pp. 1443-1456. doi: 10.1002/eji.201646763

Vancouver

Miletić A, Lenartić M, Popović B, Brizić I, Tršan T, Miklić K, and sur.. NCR1-deficiency diminishes the generation of protective murine cytomegalovirus antibodies by limiting follicular helper T-cell maturation. European Journal of Immunology [Internet]. 2017 September [cited 2024 May 13];47(9):1443-1456. doi: 10.1002/eji.201646763

IEEE

A. Miletić, et al., "NCR1-deficiency diminishes the generation of protective murine cytomegalovirus antibodies by limiting follicular helper T-cell maturation", European Journal of Immunology, vol. 47, no. 9, pp. 1443-1456, September 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:522793. [Accessed: 13 May 2024]

Cite this item: https://urn.nsk.hr/urn:nbn:hr:184:522793

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Metadata

Title (english)	NCR1-deficiency diminishes the generation of protective murine cytomegalovirus antibodies by limiting follicular helper T-cell maturation
Author	Antonija Miletić
Author	Maja Lenartić
Author	Branka Popović
Author	Ilija Brizić
Author	Tihana Tršan
Author	Karmela Miklić
Author	Ofer Mandelboim
Author	Astrid Krmpotić
Author	Stipan Jonjić
Author's institution	University of Rijeka Faculty of Medicine (Center for Proteomics)
Author's institution	University of Rijeka Faculty of Medicine (Department of Histology and Embryology)
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Basic Medical Sciences Immunology
Abstract (english)	NKp46/NCR1 is an activating NK-cell receptor implicated in the control of various viral and bacterial infections. Recent findings also suggest that it plays a role in shaping the adaptive immune response to pathogens. Using NCR1-deficient (NCR1(gfp/gfp)) mice, we provide evidence for the role of NCR1 in antibody response to mouse cytomegalovirus infection (MCMV). The absence of NCR1 resulted in impaired maturation, function and NK-cell migration to regional lymph nodes. In addition, CD4(+) T-cell activation and follicular helper T-cell (Tfh) generation were reduced, leading to inferior germinal center (GC) B-cell maturation. As a consequence, NCR1(gfp/gfp) mice produced lower amounts of MCMV-specific antibodies upon infection, which correlated with lower number of virus-specific antibody secreting cells in analyzed lymph nodes.
Keywords (english)
Language	english
Publication type	Scientific paper - Original scientific paper
Publication status	Published
Peer review	Peer review - international
Publication version	Published version
Journal title	European Journal of Immunology
Numbering	vol. 47, no. 9, pp. 1443-1456
p-ISSN	0014-2980
e-ISSN	1521-4141
DOI	https://doi.org/10.1002/eji.201646763
URN:NBN	urn:nbn:hr:184:522793
Publication	2017-09
Project	Number: 062-0621261-1263 Title (croatian): Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru Leader: Stipan Jonjić Jurisdiction: Croatia Funding stream: ZP
Document URL	https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.201646763
Type of resource	Text
Access conditions	Open access
Terms of use
Repository	Repository of the University of Rijeka, Faculty of Medicine
Created on	2017-10-01 18:11:14