Title (croatian) ENDOKRINOLOŠKI ASPEKTI SINDROMA POLICISTIČNIH JAJNIKA Title (english) ENDOCRINE ASPECTS OF POLYCYSTIC OVARY SYNDROME Author Klara Pulić Author Sanja Klobučar Majanović Author's institution University of Rijeka Scientific / art field, BIOMEDICINE AND HEALTHCARE Abstract (croatian) Sindrom policističnih jajnika, najčešći endokrinološki poremećaj u žena generativne dobi, rezultat je interakcije genetičkih svojstava jajnika i brojnih kongenitalnih i okolišnih faktora. Najvažniji postnatalni rizični čimbenik jest debljina, no osnovni je poremećaj u intraovarijskoj regulaciji steroidogeneze, obično udružen sa selektivnom inzulinskom rezistencijom. Kliničke su karakteristike sindroma oligo-amenoreja i menstrualna disfunkcija, povezane s neplodnošću, hiperandrogenizam te često prisutni udruženi rizični čimbenici za kardiovaskularne bolesti i šećernu bolest tipa 2, uključujući pretilost, hiperinzulinemiju, intoleranciju glukoze i dislipidemiju. Vrlo je bitno identificirati i redovito pratiti značajke metaboličkog sindroma te rizik od razvoja komplikacija. Prva terapijska opcija kod većine žena jest redukcija tjelesne težine koja je često dovoljna za uspostavu ovulatornih ciklusa uz povoljan utjecaj na metaboličke rizike, no katkad su potrebni i oralni kontraceptivi i antiandrogeni. U pacijentica s izraženom inzulinskom rezistencijom lijekovi koji povećavaju osjetljivost na inzulin poput metformina i tiazolidindiona važna su terapijska opcija.
Abstract (english) Polycystic ovary syndrome, the most common endocrine disorder among women of reproductive age, is a result of interaction between ovarian genetic traits and many congenital and environmental factors. The most common postnatal contributor is obesity, but the fundamental disorder is in the intraovarian regulation of steroidogenesis, often accompanied by selective insulin resistance. The syndrome is clinically characterized by oligo-amenorrhea, menstrual dysfunction, infertility, hyperandrogenism, as well as the frequent presence of associated risk factors for cardiovascular disease and diabetes, including obesity, glucose intolerance and dyslipidemia. It is very important to identify and monitor the main features of metabolic syndrome and the risk for complications. Weight loss can restore ovulatory cycles and improve metabolic risk, so it is the first-line intervention for most women, but sometimes oral contraceptives and antiandrogens have to be added. In patients with insulin resistance and associated hyperinsulinemia insulin-sensitizing agents like metformin and thiazolidinediones have important role in its treatment.
Keywords (croatian)
Sindrom policističnih jajnika – etiologija, komplikacije, patofi ziologija, liječenje
Pretilost – komplikacije, metabolizam
Hiperinzulinizam – komplikacije, patofi ziologija
Inzulinska rezistencija
Hiperandrogenizam – komplikacije, patofi ziologija
Jajnici – patofi ziologija
Metabolički sindrom – etiologija
Neplodnost kod žena – etiologija
Kardiovaskularne bolesti – etiologija
Oralni kontraceptivi – terapijska primjena
Metformin – terapijska primjena
Tiazolidindion – terapijska primjena
Keywords (english)
Polycystic ovary syndrome – complications, etiology, physiopathology, therapy
Obesity – complications, metabolism
Hyperinsulinism – complications, physopathology
Insulin resistance
Hyperandrogenism – complications, physopathology
Ovary – physiopathology
Metabolic syndrome – etiology
Infertility, female – etiology
Cardiovascular diseases – etiology
Contraceptives, oral – therapeutic use
Metformin – therapeutic use
Thiazolidinediones – therapeutic use
Language croatian Publication type Professional paper - Review paper Publication status Published Peer review Peer review Publication version Published version Journal title Liječnički vjesnik Numbering vol. 139, no. 9-10, pp. 298-305 p-ISSN 0024-3477 e-ISSN 1849-2177 URN:NBN urn:nbn:hr:184:952294 Publication 2017-12-28 Document URL https://hrcak.srce.hr/193283 Type of resource Text Access conditions Open access Terms of use Repository Repository of the University of Rijeka, Faculty of Medicine Created on 2018-02-27 12:13:45
