Title (croatian) Endotelna disfunkcija u sepsi
Title (english) Endothelial dysfunction in sepsis
Author Božena Ćurko-Cofek
Author Tanja Batinac
Author Gordana Laškarin
Author Marijana Rakić
Author Danijel Knežević
Author Alan Šustić
Author Vlatka Sotošek
Author Lara Batičić
Author's institution University of Rijeka Faculty of Medicine (Department of Chemistry and Biochemistry)
Scientific / art field, discipline and subdiscipline BIOMEDICINE AND HEALTHCARE Clinical Medical Sciences
Scientific / art field, discipline and subdiscipline BIOMEDICINE AND HEALTHCARE Basic Medical Sciences
Abstract (croatian) U fiziološkim uvjetima, endotel predstavlja dinamičku strukturu važnu u održavanju tonusa krvnih žila, regulaciji protoka krvi uz stijenke krvnih žila, vaskularne propusnosti, puteva zgrušavanja i adhezije leukocita. U sepsi, djelovanjem patogena i njihovih topljivih čimbenika dolazi do aktivacije endotela, oštećenja endotelnog glikokaliksa (EG) te pokretanja brojnih mehanizama koji imaju ključnu ulogu u razvoju i progresiji sepse. Nadalje, disfunkcija endotela i oštećenje EG ima za posljedicu snažni proupalni, prokagulacijski, proadhezivni i proapoptotični odgovor koji dovodi do disregualacije vaskularnog tonusa, povećane propusnosti krvnih žila, povećane adhezije i migracije leukocita uzrokujući razvoj šoka i višeorganskog zatajenja. U ovom preglednom radu prikazani su struktura i funkcija endotela i EG, opisani su mehanizmi njihovoga oštećenja tijekom sepse te posljedice koje nastaju njihovom disfunkcijom. Nadalje, iznijete su do sada poznate činjenice o metodama detekcije endotelne disfunkcije te mogućnostima njenog liječenja u sepsi s ciljem unapređenja liječenja septičnih bolesnika.
Abstract (english) Under physiological conditions, the endothelium is a dynamic structure important for maintaining blood vessel tone, regulating blood flow along vessel walls, vascular permeability, coagulation pathways, and leukocyte adhesion. In sepsis, exposure to pathogens and their soluble factors leads to activation of the endothelium, damage to the endothelial glycocalyx (EG), and initiation of numerous mechanisms that play a key role in the development and progression of sepsis. In addition, endothelial dysfunction and damage to the EG result in a potent proinflammatory, procoagulant, proadhesive, and proapoptotic response, leading to dysregulation of vascular tone, increased vascular permeability, increased leukocyte adhesion and migration, and the development of shock and multiorgan failure. In this review, the structure and function of the endothelium and EG are summarized and the mechanisms of their damage during sepsis as well as the consequences of their dysfunction are described. In addition, available knowledge about the methods of detecting endothelial dysfunction and the
possibilities of its treatment in sepsis are presented, with the aim of improving the treatment of septic patients.
Keywords (croatian)
ENDOTEL
ENDOTELNA DISFUNKCIJA
ENDOTELNI GLIKOKALIKS
SEPSA
Keywords (english)
ENDOTHEL
ENDOTHELIAL DYSFUNCTION
ENDOTHELIAL GLYCOCAYLX
SEPSIS
Language croatian
Language english
Publication type Scientific paper - Case study
Publication status Published
Peer review Peer review
Publication version Published version
Journal title Liječnički vjesnik
Numbering vol. 145, no. Supp 4, pp. 24-34
p-ISSN 0024-3477
e-ISSN 1849-2177
DOI https://doi.org/10.26800/LV-145-supl4-7
URN:NBN urn:nbn:hr:184:094542
Publication 2023-11-20
Project Number: uniri-biomed-18-40 Title (croatian): Karakterizacija endotelne disfunkcije i uloga IL-18 u razvoju ishemijsko reperfuzijske ozljede nakon kirurške revaskularizacije miokarda Title (english): Characteristics of endothelial disfunction and the role of IL-18 in ischaemic-reperfusion injury after coronary artery bypass grafting Leader: Vlatka Sotošek Jurisdiction: Croatia Funding stream: Nema
Document URL https://hrcak.srce.hr/310061
Type of resource Text
Access conditions Open access
Terms of use
Repository Repository of the University of Rijeka, Faculty of Medicine
Created on 2023-11-30 07:43:18