prikaz prve stranice dokumenta Virus-induced cochlear inflammation in newborn mice alters auditory function
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Virus-induced cochlear inflammation in newborn mice alters auditory function
Journal of Clinical Investigation Insight, 4 (2019), 17; 128878. https://doi.org/10.1172/jci.insight.128878
Sung, Cathy Yea Won; Seleme, Maria C.; Payne, Shelby; Jonjić, Stipan; Hirose, Keiko; Britt, William J.

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Sung, C. Y. W., Seleme, M. C., Payne, S., Jonjić, S., Hirose, K. i Britt, W. J. (2019). Virus-induced cochlear inflammation in newborn mice alters auditory function. Journal of Clinical Investigation Insight, 4. (17). doi: 10.1172/jci.insight.128878

Sung, Cathy Yea Won, et al. "Virus-induced cochlear inflammation in newborn mice alters auditory function." Journal of Clinical Investigation Insight, vol. 4, br. 17, 2019. https://doi.org/10.1172/jci.insight.128878

Sung, Cathy Yea Won, Maria C. Seleme, Shelby Payne, Stipan Jonjić, Keiko Hirose i William J. Britt. "Virus-induced cochlear inflammation in newborn mice alters auditory function." Journal of Clinical Investigation Insight 4, br. 17 (2019). https://doi.org/10.1172/jci.insight.128878

Sung, C. Y. W., et al. (2019) 'Virus-induced cochlear inflammation in newborn mice alters auditory function', Journal of Clinical Investigation Insight, 4(17). doi: 10.1172/jci.insight.128878

Sung CYW, Seleme MC, Payne S, Jonjić S, Hirose K, Britt WJ. Virus-induced cochlear inflammation in newborn mice alters auditory function. Journal of Clinical Investigation Insight [Internet]. 05.09.2019. [pristupljeno 25.04.2024.];4(17). doi: 10.1172/jci.insight.128878

C. Y. W. Sung, M. C. Seleme, S. Payne, S. Jonjić, K. Hirose i W. J. Britt, "Virus-induced cochlear inflammation in newborn mice alters auditory function", Journal of Clinical Investigation Insight, vol. 4, br. 17, Rujan 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:382693. [Citirano: 25.04.2024.]

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Naslov (engleski)Virus-induced cochlear inflammation in newborn mice alters auditory function
AutorCathy Yea Won Sung
AutorMaria C. Seleme
AutorShelby Payne
AutorStipan Jonjić
AutorKeiko Hirose
AutorWilliam J. Britt
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Although human cytomegalovirus (HCMV) is a known cause of sensorineural hearing loss in infants with congenital HCMV (cCMV) infections, mechanisms that contribute to sensorineural hearing loss (SNHL) in infants with cCMV infection are not well defined. Using a murine model of CMV infection during auditory development, we have shown that peripheral infection of newborn mice with murine CMV (MCMV) results in focal infection of the cochlea and virus-induced cochlear inflammation. Approximately 50%-60% of infected mice exhibited increased auditory brainstem response (ABR) thresholds across a range of sound frequencies. Histological analyses of the cochlea in MCMV-infected mice with elevated ABR thresholds revealed preservation of hair cell (HC) number and morphology in the organ of Corti. In contrast, the number of spiral ganglion neurons (SGN), synapses, and neurites connecting the cochlear HC and SGN nerve terminals were decreased. Decreasing cochlear inflammation by corticosteroid treatment of MCMV-infected mice resulted in preservation of SGN and improved auditory function. These findings show that virus-induced cochlear inflammation during early auditory development, rather than direct virus-mediated damage, could contribute to histopathology in the cochlea and altered auditory function without significant loss of HCs in the sensory epithelium.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Clinical Investigation Insight
Brojčani podacivol. 4, br. 17, 128878
e-ISSN2379-3708
DOIhttps://doi.org/10.1172/jci.insight.128878
URN:NBNurn:nbn:hr:184:382693
Datum objave publikacije2019-09-05
URL dokumentahttps://insight.jci.org/articles/view/128878
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
RepozitorijRepozitorij Medicinskog fakulteta u Rijeci
Datum i vrijeme pohrane2019-09-10 13:10:17